Here are a few good Honduras travel information resources that I came across:
The State Department maintains general information on countries & travel information. Always a good place to start...
The CDC Traveler’s Health site for Honduras lists all the recommended vaccinations and has health related travel information for the region:
I've found the SidewalkMystic.com site to have tons of useful travel tips covering food, culture, travel, and more. You should definitely read the travel packing, preparations, transportation, money, and safety sections.
Although a bit more of a commercial site, there is some Siguatepeque specific information on honduras.com.
Also, check out some videos from those who have done Honduras missions before on YouTube. Search for Honduras Mission, Siguatepeque Honduras Mission, or other variations.